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Können Depressionen mit Hilfe von Botox erfolgreich behandelt werden? Eine neue Meta-Analyse von Schulze und Kollegen (2021) sorgt in der Wissenschafts-Welt für Furore. Der Studie zufolge soll Botox 3 mal effektiver sein als herkömmliche Antidepressiva …


Studien (nur kleine Auswahl):

Brin, M.F., Durgam, S., Lum, A., James, L., Liu, J., Thase, M.E., Szegedi, A., 2020. OnabotulinumtoxinA for the treatment of major depressive disorder: a phase 2 randomized, double-blind, placebo-controlled trial in adult females. Int. Clin. Psychopharmacol. 35, 19–28.

Coles, N. A., Larsen, J. T., Kuribayashi, J., & Kuelz, A. (2019). Does blocking facial feedback via botulinum toxin injections decrease depression? A critical review and meta-analysis. Emotion Review, 11(4), 294-309.

Coles, N. A., & Larsen, J. (2021). Letter to the Editor: Claims about the effects of botulinum toxin on depression should raise some eyebrows.

Finzi, E., Rosenthal, N.E., 2016. Emotional proprioception: treatment of depression with afferent facial feedback. J. Psychiatr. Res. 80, 93–96. jpsychires.2016.06.009.

Magid, M., Finzi, E., Kruger, T. H. C., Robertson, H. T., Keeling, B. H., Jung, S., … & Wollmer, M. A. (2015). Treating depression with botulinum toxin: a pooled analysis of randomized controlled trials. Pharmacopsychiatry, 25(06), 205-210.

Magid, M., Reichenberg, J. S., Poth, P. E., Robertson, H. T., LaViolette, A. K., Kruger, T. H., & Wollmer, M. A. (2014). Treatment of major depressive disorder using botulinum toxin A: a 24-week randomized, double-blind, placebo-controlled study. The Journal of clinical psychiatry, 75(8), 0-0.

O’Grady, C. (2021). Botox depression treatment raises eyebrows.

Qian, H., Shao, F., Lenahan, C., Shao, A., & Li, Y. (2020). Efficacy and safety of botulinum toxin vs. placebo in depression: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Psychiatry, 11, 1267.

Parsaik, A. K., Mascarenhas, S. S., Hashmi, A., Prokop, L. J., John, V., Okusaga, O., & Singh, B. (2016). Role of botulinum toxin in depression. Journal of Psychiatric Practice®, 22(2), 99-110.

Schulze, J., Neumann, I., Magid, M., Finzi, E., Sinke, C., Wollmer, M. A., & Krüger, T. H. (2021). Botulinum toxin for the management of depression: An updated review of the evidence and meta-analysis. Journal of Psychiatric Research.

Wollmer, M. A., Magid, M., Kruger, T. H., & Finzi, E. (2019). The use of botulinum toxin for treatment of depression. In Botulinum Toxin Therapy (pp. 265-278). Springer, Cham.


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